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Join the fight against Alzheimer’s disease

The ABATE Study is testing an investigational vaccine for Alzheimer’s disease in people with Down syndrome.

People with Down syndrome often get Alzheimer’s disease (a type of dementia) when they get older. Dementia is a disease that causes memory loss and other thinking problems. Dementia due to Alzheimer’s occurs when a protein called amyloid builds up in the brain.

About ABATE Study

Watch the video here

The ABATE Study is testing a vaccine for Alzheimer’s.

We want to see if the vaccine is safe. We also want to see if it slows the progression of Alzheimer’s disease in people with Down syndrome.

About 80 people with Down syndrome will take part in the ABATE Study.

The study is being conducted in collaboration with the Alzheimer’s Clinical Trials Consortium – Down Syndrome – ACTC-DS.

Who is eligible for the ABATE Study?

You may be able to join this study if you:

Have Down Syndrome

Are between 35 and 50 years old

Have a study partner

Your study partner is someone who could support you during your participation. For example, they could be a family member or any relative close to you, or a carer.

If you are interested, please contact your nearest research center to learn more about the ABATE Study and check your eligibility.

Locations

What is the study treatment?

The study treatment, ACI-24.060, is a new vaccine which is not yet on the market. It may help to remove amyloid in the brain. This could slow down memory loss and thinking problems.
In the ABATE Study, you will receive either the vaccine or an inactive vaccine (also called placebo). This is so we can see how the vaccine affects your body. Neither you nor the study team will know which vaccine you are getting.

You will get the vaccine or inactive vaccine, as well as any tests and visits for the study, at no cost.

What happens in the ABATE Study?

The study lasts for about 2 years and is split into 3 parts:

Screening period
The study team will do tests to see if you meet the criteria to join the study. If you can join, you and your study partner will sign consent forms before you begin.
Treatment period
You will get either the vaccine or inactive vaccine 6 times. You will also have visits at the study clinic and phone calls so the study team can check your health and check how the vaccine is working in your body.
Follow-up period
You won’t get the vaccine or inactive vaccine anymore. You will have some visits to check your health and see how the vaccine is working in your body.