People with Down syndrome often get Alzheimer’s disease (a type of dementia) when they get older. Dementia is a disease that causes memory loss and other thinking problems. Dementia due to Alzheimer’s occurs when a protein called amyloid builds up in the brain.
About ABATE Study
The ABATE Study is testing a vaccine for Alzheimer’s.
We want to see if the vaccine is safe. We also want to see if it slows the progression of Alzheimer’s disease in people with Down syndrome.
About 80 people with Down syndrome will take part in the ABATE Study.
The study is being conducted in collaboration with the Alzheimer’s Clinical Trials Consortium – Down Syndrome – ACTC-DS.
Who is eligible for the ABATE Study?
You may be able to join this study if you:
Have Down Syndrome
Are between 35 and 50 years old
Have a study partner
Your study partner is someone who could support you during your participation. For example, they could be a family member or any relative close to you, or a carer.
If you are interested, please contact your nearest research center to learn more about the ABATE Study and check your eligibility.
What is the study treatment?
The study treatment, ACI-24.060, is a new vaccine which is not yet on the market. It may help to remove amyloid in the brain. This could slow down memory loss and thinking problems.
In the ABATE Study, you will receive either the vaccine or an inactive vaccine (also called placebo). This is so we can see how the vaccine affects your body. Neither you nor the study team will know which vaccine you are getting.
You will get the vaccine or inactive vaccine, as well as any tests and visits for the study, at no cost.
What happens in the ABATE Study?
The study lasts for about 2 years and is split into 3 parts:
Screening period
The study team will do tests to see if you meet the criteria to join the study. If you can join, you and your study partner will sign consent forms before you begin.
Treatment period
You will get either the vaccine or inactive vaccine 6 times. You will also have visits at the study clinic and phone calls so the study team can check your health and check how the vaccine is working in your body.
Follow-up period
You won’t get the vaccine or inactive vaccine anymore. You will have some visits to check your health and see how the vaccine is working in your body.
USA
Coming Soon
Vanderbilt University Medical Center
Center for Cognitive medecine
Amy Boegel
615-875-0955
amy.r.boegel@vumc.org
1601 23rd Avenue South,
37212, Nashville, Tennessee
Now enrolling
University of Kansas Medical Center
Alzheimer’s Disease Research Center
Keri Cox
913-945-7037
kcox11@kumc.edu
4350 Shawnee Mission Parkway, Suite 1200, 66205, Fairway, Kansas
Now enrolling
Barrow Neurological Institute
Alzheimer’s Disease and Memory Disorders Division
Jalisa Santiago
800-392-2222
jalisa.santiago@commonspirit.org
240 W Thomas Rd,
Suite 301,
85013, Phoenix, Arizona
Coming Soon
Washington University in St. Louis
Britany Nelson
314-747-8425
bmnelson@wustl.edu
660 S. Euclid, CB 8111,
63110, St-Louis, Missouri
Now enrolling
Massachusetts General Hospital (MGH)
Mikayla Shaffer
617-643-8912
researchdownsyndrome@mgh.harvard.edu
185 Cambridge Street,
Suite 2.222,
02114, Boston, Massachusetts
Now enrolling
Indiana University / IU Health
Neuroscience Center
Kate Phillips
317-278-3260
philkate@iu.edu
355 W 16th Street, 46202, Indianapolis, Indiana
Now enrolling
UT Health San Antonio
Biggs Institute for Alzheimer’s and Neurodegenerative Diseases
Floyd Jones
210-450-3158
jonesfa@uthscsa.edu
MC 8070, 7703 Floyd Curl Dr.
78229, San Antonio, Texas
UK
Now enrolling
King’s College London
Institute of Psychiatry, Psychology and Neuroscience
Charlie Mizon
07743754760
Charles.mizon@kcl.ac.uk
16 De Crespigny Park, London, SE5 8AF
Now enrolling
Windsor Research Unit
Fulbourn Hospital
Madelaine Smith & Blessing Ushie
07837067964
madelaine.smith9@cpft.nhs.uk or blessing.ushie@cpft.nhs.uk
Fulbourn Hospital, Cambridge,CB21 5EF
Now enrolling
NIHR Oxford Health Clinical Research Facility
Warneford Hospital
Abigail Stewart & Rachel Delahay
01865902135
Abigail1.Stewart@oxfordhealth.nhs.uk Rachel.Delahay@oxfordhealth.nhs.uk oxfordhealth.crf@nhs.net
Warneford Lane, Oxford, OX3 7JX
Spain
Now enrolling
Hospital de la Santa Creu I Sant Pau
Juan Fortea & Isabel Barroeta
jfortea@santpau.cat & ibarroeta@santpau.cat
C/ Mas casanovas, 90. Bloc A, planta -2 (AGDAC), 08025, Barcelona
Now enrolling
Hospital Universitario de la Princesa
Fernando Moldenhauer Diaz
915 202 222
fernando.moldenhauer@salud.madrid.org
Calle de Diego de León, 62,28006, Madrid
Now enrolling
Hospital Universitario Marqués de Valdecilla
Unidad de Deterioro Cognitivo, Servicio de Neurología
Eloy Rodriguez & Andrea Corrales
942 202 520 extensión73650
Deterioro.cognitivo.humv@scsalud.es
Av. de Valdecilla, 25,39008, Santander
Now enrolling
Hospital Universitario Virgen De Las Nieves
Consultas Externas
Elizabeth Garcia Penalver
958 895 426
eligarpe28@hotmail.com
Calle Dr. Azpitarte 4, ( 5ª planta), 18012, Granada